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Complication Rates of Below Knee Amputation Wounds with use of Injectable Micronized Human Amniotic Membrane Allograft: A Single Center Case Series
Justin George, M.D.1, Joshuva John, B.S.2, David Finlay, M.D.1, John Ko, M.D.1, Rajiv Chander, M.D.1.
1Mount Sinai, New York, NY, USA, 2Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

Objective(s): Below the knee amputation (BKA) is a common procedure performed in the United States and is often complicated by wound dehiscence. Human amniotic membrane allografts have been shown to improve wound healing. The purpose of this study is to evaluate the wound complication rate in patients who underwent BKA with simultaneous administration of an injectable amniotic membrane allograft.
Methods:
All patients undergoing BKA with intraoperative administration of micronized amniotic membrane allograft at a single institution were included. These cases underwent chart review and were evaluated for wound complication, need for surgical reintervention, and length of hospital stay.
Results:
Seven patients underwent BKA with amniotic membrane allograft administration. One patient (14.3%) had wound dehiscence requiring surgical reintervention. Mean hospital stay was 8.29 5.94 days.
Conclusions:
BKA wound dehiscence rate appears lower in patients who received micronized amniotic membrane allograft when compared to the previously published rate of wound complication after major amputation. Micronized amniotic membrane allografts may improve wound healing by providing several growth factors and modulating the inflammatory response. These findings warrant larger studies.

Characteristics of Patients receiving BKA with Micronized Amniotic Membrane Allograft Injection
Age (Avg Std)69.1 9.12
Male100% (7)
African American57.1% (4)
Caucasian42.9% (3)


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